DOI: https://doi.org/10.22141/2309-8147.7.1.2019.163007

The effectiveness of Travinor® and Dorzitim® eye drops in the treatment of primary open-angle glaucoma and some biomorphometric correlations

M.V. Sydorova

Abstract


Background. Effective reduction of intraocular pressure (IOP) is the basis for achieving the target pressure. Purpose was to evaluate the effectiveness of Travinor® (travoprost 0.004%) and the combined antiglaucoma drops Dorzitim® (dorzolamide hydrochloride 2% + timolol maleate 0.5%) in the treatment of primary open-angle glaucoma and also to determine the morphometric correlations of the optic nerve parameters and the central corneal thickness in patients with different stages of primary open-angle glaucoma. Materials and methods. The study included 45 patients (90 eyes) with newly diagnosed open-angle glaucoma stages І, ІІ and ІІІ. Patients with IOP up to 24 mmHg inclusive were prescribed Travinor® as monotherapy, and in greater IOP — the combination of Travinor® with 0.5% timolol or Travinor® with Dorzitim®. IOP parameters were evaluated one, two and three weeks after. Results. The dynamics of IOP reduction on Travinor® monotherapy was 8.54 mmHg within one month of observation (from 24.81 ± 0.93 mmHg to 16.27 ± 0.44 mmHg (p < 0.01, n = 17)). Combined therapy with Travinor® and timolol 0.5% showed a decrease in IOP from 28.14 ± 3.37 mmHg to 19.52 ± 1.94 mmHg (p < 0.01, n = 19), the mean difference from baseline is 8.62 mmHg, that is, 30.63%. In the group of Travinor® and Dorzitim® (n = 9) combination, IOP reduced from 30.5 ± 1.9 mmHg to 20.62 ± 2.05 mmHg (p < 0.01, n = 9), the difference from baseline is 32.93%. Conclusions. Travinor® and Dorzitim® are effective and safe drugs for the treatment of glaucoma, both as monotherapy and in combination.


Keywords


primary open-angle glaucoma; combined treatment; travoprost; dorzolamide hydrochloride; timolol maleate

References


Moskalenko V.F., Rykov C.O., Vitovvka O.P., Varyvonchyk D.V. Scientific justification of the concept of the national strategy for the control of glaucoma in Ukraine. Medical Practice. 2010 Jan-Feb: 121-126. In Ukrainian.

European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition – Chapter 3: Treatment principles and options Supported by the EGS Foundation: Br J Ophthalmol. 2017 Jun;101(6):130-195.

European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition – Chapter 2: Classification and Terminology Supported by the EGS Foundation: Br J Ophthalmol. 2017 May;101(5):73-127.


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