The effectiveness of Travinor® and Dorzitim® eye drops in the treatment of primary open-angle glaucoma and some biomorphometric correlations
Background. Effective reduction of intraocular pressure (IOP) is the basis for achieving the target pressure. Purpose was to evaluate the effectiveness of Travinor® (travoprost 0.004%) and the combined antiglaucoma drops Dorzitim® (dorzolamide hydrochloride 2% + timolol maleate 0.5%) in the treatment of primary open-angle glaucoma and also to determine the morphometric correlations of the optic nerve parameters and the central corneal thickness in patients with different stages of primary open-angle glaucoma. Materials and methods. The study included 45 patients (90 eyes) with newly diagnosed open-angle glaucoma stages І, ІІ and ІІІ. Patients with IOP up to 24 mmHg inclusive were prescribed Travinor® as monotherapy, and in greater IOP — the combination of Travinor® with 0.5% timolol or Travinor® with Dorzitim®. IOP parameters were evaluated one, two and three weeks after. Results. The dynamics of IOP reduction on Travinor® monotherapy was 8.54 mmHg within one month of observation (from 24.81 ± 0.93 mmHg to 16.27 ± 0.44 mmHg (p < 0.01, n = 17)). Combined therapy with Travinor® and timolol 0.5% showed a decrease in IOP from 28.14 ± 3.37 mmHg to 19.52 ± 1.94 mmHg (p < 0.01, n = 19), the mean difference from baseline is 8.62 mmHg, that is, 30.63%. In the group of Travinor® and Dorzitim® (n = 9) combination, IOP reduced from 30.5 ± 1.9 mmHg to 20.62 ± 2.05 mmHg (p < 0.01, n = 9), the difference from baseline is 32.93%. Conclusions. Travinor® and Dorzitim® are effective and safe drugs for the treatment of glaucoma, both as monotherapy and in combination.
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Moskalenko V.F., Rykov C.O., Vitovvka O.P., Varyvonchyk D.V. Scientific justification of the concept of the national strategy for the control of glaucoma in Ukraine. Medical Practice. 2010 Jan-Feb: 121-126. In Ukrainian.
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