L. Yu. Pylypenko, V. M. Serdiuk


Background. One of the key roles in the development of diabetic retinopathy (DRP) is capillary occlusion. As a possible mechanism of this phenomenon is the increase of the leukocytes adhesion to the endothelium due to high expression of adhesive molecules in the microcirculatory space of the retina.

Purpose. To study the content of the vascular cell adhesion molecule VCAM-1 in the blood at different stages of the DRP.
Material and methods. The research was carried out with 64 patients (95 eyes) with at type 2 diabetes mellitus (T2DM), metabolic syndrome (MS) and DRP (age 61.55±2.37 years old, length of diabetes 11.23±2.11 years, level of HbA1C 9.89±0.78 %, BMI 34.55±3.75 kg/m2), who were divided into 3 groups depending on the stage of DRP. Exclusion criteria for this study were: type 1 diabetics, mental disorders, age less than 18 years, severe comorbidities such as congestive heart failure, liver disease, malignancy, infl ammatory process, pregnancy, or any factor affecting body weight such as hypothyroidism, corticosteroids (Cushing’s syndrome), or contraceptives. Written informed consent was obtained from all subjects prior to the inclusion into the study. The ANOVA and regression analysis were used as statistical analysis.
Results. The highest value of the VCAM-1 level of blood was in the nonproliferative stage of DRP (3.45±0.39 pg/ml). Regardless of the stage of the DRP, a signifi cant direct linear relationship was found between VCAM-1 and fi brinogen of the blood (r=0.59, R2=35.1 %, p=0.01). The tendency in the direct dependence of the VCAM-1 content and the duration of T2DM was revealed (r=0.25, R2=6.5 %, p=0.05).
Conclusions. Possible participation of VCAM-1 together with fi brinogen in the formation of leukostasis and capillary occlusion, especially in the nonproliferative stage of DRP was traced.


diabetic retinopathy, VCAM-1, type 2 diabetes mellitus, metabolic syndrome


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