N. V. Malachkova, M. L. Kyryliuk, I. V. Komarovska


Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of visual impairment and blindness. The aim of the study was to examine the hormonal activity of adipose tissue in patients with type 2 diabetes mellitus (DMT2) and obesity based on the study of the level of adiponectin and resistin in the blood at different stages of DR, taking into account the age of patients, the length of diabetes and the degree of its compensation. 23 subjects with obesity and without DMT2 (individuals of both sexes, mean age 56.60±4.83 years) and 79 patients of both sexes with DMT2, obesity and DR were examined (mean age 59.78±4.09 years, average length of diabetes 9,99±2,64 years, the average level of glycated hemoglobin (HbA1C) 10.62±1.99 %). Using the ANOVA method and discriminant analysis, it was established that the severity of DR is signifi cantly (p=0.040) and positively associated with the serum resistin concentrations in patients with DMT2. A decrease of the adiponectin serum concentration is statistically associated with a loss of the glycemic control on the background of DR progresses (p=0.007). A conclusion has been drawn on the relationship between the hormones of adipose tissue and the development of DR.


diabetic retinopathy, adiponectin, resistin


Сердюк В. Н. Морфометрические и биохимические кластеры метаболического синдрома у пациентов с сахарным диабетом 2-го типа на разных стадиях диабетической ретинопатии / В. Н. Сердюк, В. А. Ищенко // Международный эндокринологический журнал. – 2016. – Т. 79, № 7. – С. 69–74.

Сердюк В. Н. Содержание лептина в крови у пациентов с сахарным диабетом 2-го типа на разных стадиях диабетической ретинопатии / В. Н. Сердюк, В. А. Ищенко // Офтальмологія.– 2017.– № 1 (06). – С. 46–54.

Флетчер Р. Клиническая эпидемиология. Основы доказательной медицины: [монография] / Р. Флетчер, С. Флетчер, Э. Вагнер. – М.: Медиа Сфера, 1998. – 347 с.

Bełtowski J. Adiponectin and resistin – new hormones of white adipose tissue / J. Bełtowski // Medical Science Monitor. – 2003. – 9. – RA 55–61.

Hadjadj S. Increased plasma adiponectin concentrations are associated with microangiopathy in type 1 diabetic subjects / S. Hadjadj, R. Aubert, F. Fumeron [et al.] // Diabetologia. – 2005. – Vol. 48. – Р. 1088–1092.

Matsuda M. Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese type 2 diabetic subjects / M. Matsuda, F. Kawasaki, K. Yamada [et al.] // Diabet Med. – 2004. – Vol. 21. – P. 881–888.

Azab Naglaa. Correlation of serum resistin level with insulin resistance and severity of retinopathy in type 2 diabetes mellitus / Naglaa Azab, Taher Abdel-Aziz, Amr Ahmed, I. M. El-deen // Journal of Saudi Chemical Society. – 2016. – Vol. 20 (3). – P. 272–277.

Osawa H. Serum resistin is associated with the severity of microangiopathies in type 2 diabetes / H. Osawa, M. Ochi, K. Kato [et al.] // Biochem Biophys Res Commun. – 2007. – Vol. 355 (2). – P. 342–346.

Parvanova A. Insulin resistance and proliferative retinopathy: a cross-sectional, case-control study in 115 patients with type 2 diabetes / A. Parvanova, I. Iliev, M. Filipponi [et al.] // The Journal of Clinical Endocrinology & Metabolism. – 2004. – Vol. 89 (9). – P. 4371–4376.

Silha J. V. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance / J.V. Silha, M. Krsek, J. V. Skrha [et al.] // Eur J Endocrinol. – 2003. – Vol. 149. – Р. 331–335.

Use of glycated haemoglobin (HbA1c) in the diagnosis of diabetes mellitus: abbreviated report of a WHO consultation (WHO/NMH/CHP/CPM/11.1) /World Health Organization. – Geneva: WHO. – 2011. – 25 p.

Zietz B. Serum levels of adiponectin are associated with diabetic retinopathy and with adiponectin gene mutations in Caucasian patients with diabetes mellitus type 2 / B. Zietz, C. Buechler, K. Kobuch [et al.] // Exp Clin Endocrinol Diabetes. – 2008. – Vol. 116. – P. 532–536.


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