DOI: https://doi.org/10.22141/2309-8147.5.3.2017.172348

HORMONAL ACTIVITY OF ADIPOSE TISSUE IN PATIENTS WITH TYPE II DIABETES AT DIFFERENT STAGES OF DIABETIC RETINOPATHY

N. V. Malachkova, M. L. Kyryliuk, I. V. Komarovska

Abstract


Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of visual impairment and blindness. The aim of the study was to examine the hormonal activity of adipose tissue in patients with type 2 diabetes mellitus (DMT2) and obesity based on the study of the level of adiponectin and resistin in the blood at different stages of DR, taking into account the age of patients, the length of diabetes and the degree of its compensation. 23 subjects with obesity and without DMT2 (individuals of both sexes, mean age 56.60±4.83 years) and 79 patients of both sexes with DMT2, obesity and DR were examined (mean age 59.78±4.09 years, average length of diabetes 9,99±2,64 years, the average level of glycated hemoglobin (HbA1C) 10.62±1.99 %). Using the ANOVA method and discriminant analysis, it was established that the severity of DR is signifi cantly (p=0.040) and positively associated with the serum resistin concentrations in patients with DMT2. A decrease of the adiponectin serum concentration is statistically associated with a loss of the glycemic control on the background of DR progresses (p=0.007). A conclusion has been drawn on the relationship between the hormones of adipose tissue and the development of DR.


Keywords


diabetic retinopathy, adiponectin, resistin

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