HORMONAL ACTIVITY OF ADIPOSE TISSUE IN PATIENTS WITH TYPE II DIABETES AT DIFFERENT STAGES OF DIABETIC RETINOPATHY
Keywords:diabetic retinopathy, adiponectin, resistin
Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of visual impairment and blindness. The aim of the study was to examine the hormonal activity of adipose tissue in patients with type 2 diabetes mellitus (DMT2) and obesity based on the study of the level of adiponectin and resistin in the blood at different stages of DR, taking into account the age of patients, the length of diabetes and the degree of its compensation. 23 subjects with obesity and without DMT2 (individuals of both sexes, mean age 56.60±4.83 years) and 79 patients of both sexes with DMT2, obesity and DR were examined (mean age 59.78±4.09 years, average length of diabetes 9,99±2,64 years, the average level of glycated hemoglobin (HbA1C) 10.62±1.99 %). Using the ANOVA method and discriminant analysis, it was established that the severity of DR is signifi cantly (p=0.040) and positively associated with the serum resistin concentrations in patients with DMT2. A decrease of the adiponectin serum concentration is statistically associated with a loss of the glycemic control on the background of DR progresses (p=0.007). A conclusion has been drawn on the relationship between the hormones of adipose tissue and the development of DR.
Сердюк В. Н. Морфометрические и биохимические кластеры метаболического синдрома у пациентов с сахарным диабетом 2-го типа на разных стадиях диабетической ретинопатии / В. Н. Сердюк, В. А. Ищенко // Международный эндокринологический журнал. – 2016. – Т. 79, № 7. – С. 69–74.
Сердюк В. Н. Содержание лептина в крови у пациентов с сахарным диабетом 2-го типа на разных стадиях диабетической ретинопатии / В. Н. Сердюк, В. А. Ищенко // Офтальмологія.– 2017.– № 1 (06). – С. 46–54.
Флетчер Р. Клиническая эпидемиология. Основы доказательной медицины: [монография] / Р. Флетчер, С. Флетчер, Э. Вагнер. – М.: Медиа Сфера, 1998. – 347 с.
Bełtowski J. Adiponectin and resistin – new hormones of white adipose tissue / J. Bełtowski // Medical Science Monitor. – 2003. – 9. – RA 55–61.
Hadjadj S. Increased plasma adiponectin concentrations are associated with microangiopathy in type 1 diabetic subjects / S. Hadjadj, R. Aubert, F. Fumeron [et al.] // Diabetologia. – 2005. – Vol. 48. – Р. 1088–1092.
Matsuda M. Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese type 2 diabetic subjects / M. Matsuda, F. Kawasaki, K. Yamada [et al.] // Diabet Med. – 2004. – Vol. 21. – P. 881–888.
Azab Naglaa. Correlation of serum resistin level with insulin resistance and severity of retinopathy in type 2 diabetes mellitus / Naglaa Azab, Taher Abdel-Aziz, Amr Ahmed, I. M. El-deen // Journal of Saudi Chemical Society. – 2016. – Vol. 20 (3). – P. 272–277.
Osawa H. Serum resistin is associated with the severity of microangiopathies in type 2 diabetes / H. Osawa, M. Ochi, K. Kato [et al.] // Biochem Biophys Res Commun. – 2007. – Vol. 355 (2). – P. 342–346.
Parvanova A. Insulin resistance and proliferative retinopathy: a cross-sectional, case-control study in 115 patients with type 2 diabetes / A. Parvanova, I. Iliev, M. Filipponi [et al.] // The Journal of Clinical Endocrinology & Metabolism. – 2004. – Vol. 89 (9). – P. 4371–4376.
Silha J. V. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance / J.V. Silha, M. Krsek, J. V. Skrha [et al.] // Eur J Endocrinol. – 2003. – Vol. 149. – Р. 331–335.
Use of glycated haemoglobin (HbA1c) in the diagnosis of diabetes mellitus: abbreviated report of a WHO consultation (WHO/NMH/CHP/CPM/11.1) /World Health Organization. – Geneva: WHO. – 2011. – 25 p.
Zietz B. Serum levels of adiponectin are associated with diabetic retinopathy and with adiponectin gene mutations in Caucasian patients with diabetes mellitus type 2 / B. Zietz, C. Buechler, K. Kobuch [et al.] // Exp Clin Endocrinol Diabetes. – 2008. – Vol. 116. – P. 532–536.
Copyright (c) 2019 Archive of Ukrainian Ophthalmology
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our edition uses the copyright terms of Creative Commons for open access journals.
Authors, who are published in this journal, agree with the following terms:
- The authors retain rights for authorship of their article and grant to the edition the right of first publication of the article on a Creative Commons Attribution 4.0 International License, which allows others to freely distribute the published article, with the obligatory reference to the authors of original works and original publication in this journal.
- Directing the article for the publication to the editorial board (publisher), the author agrees with transmitting of rights for the protection and using the article, including parts of the article, which are protected by the copyrights, such as the author’s photo, pictures, charts, tables, etc., including the reproduction in the media and the Internet; for distributing; for the translation of the manuscript in all languages; for export and import of the publications copies of the writers’ article to spread, bringing to the general information.
- The rights mentioned above authors transfer to the edition (publisher) for the unlimited period of validity and on the territory of all countries of the world.
- The authors guarantee that they have exclusive rights for using of the article, which they have sent to the edition (publisher). The edition (the publisher) is not responsible for the violation of given guarantees by the authors to the third parties.
- The authors have the right to conclude separate supplement agreements that relate to non-exclusive distribution of their article in the form in which it had been published in the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
- The policy of the journal permits and encourages the publication of the article in the Internet (in institutional repository or on a personal website) by the authors, because it contributes to productive scientific discussion and a positive effect on efficiency and dynamics of the citation of the article.
- The rights to the article are deemed transferred by the authors to the edition (the publisher) since the moment of the publication of the article in the printed or electronic version of journal.