THE FEATURES OF BLOOD PRESSURE IN PATIENTS WITH DIABETIC RETINOPATHY, TYPE 2 DIABETES AND ADIPOSITY
Introduction. Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of visual impairment and blindness. Research has established the importance of blood glucose control to prevent development and progression of the ocular complications of diabetes. Simultaneous blood pressure control has been advocated for the same purpose, but fi ndings reported from individual studies have supported varying conclusions regarding the ocular benefi t of interventions on blood pressure.
The aim of the work is to examine the level of systolic (SBP) and diastolic (DBP) blood pressure in patients with type 2 diabetes mellitus (T2DM), obese and diabetic retinopathy (DR) according to the modifi ed risk factors of its occurrence and progression.
Materials and methods. The study involved 20 people with overweight or obesity without T2DM (individuals of both sexes, average age – 57,46 ± 4,46 years) and 117 patients of both sexes with T2DM, obesity, diabetic retinopathy (mean age is 59,61 ± 3,23 years, the average length of diabetes is 9,23 ± 2,04 years, the average level of glycated hemoglobin (HbA1C) is 10,78 ± 1,59 %).
Results and discussion. The early stages of non-proliferative DR are characterized by the greatest SBP in patients aged over 60 years, with duration of diabetes more than 10 years, when the content of HbA1C is less than 8 %, the worst performance of DBP during therapy by oral hypoglycemic agents. The favorable indicators of DBP were found in patients aged over 60 years, with experience of T2DM less than 10 years, when blood level of HbA1C is less than 8 % and when insulin therapy was applied. Further progression of non-proliferative stage of DR is characterized by the highest levels of SBP during therapy by oral hypoglycemic agents, when HbA1C blood levels are less than 8 %. The proliferative stage of DR is characterized by the worst levels of SBP in patients under the age of 60 years, with a length of type 2 diabetes up to 10 years, with HbA1C blood levels more than 8 %, when insulin therapy was applied. Adverse statistically signifi cant changes of DBP levels were detected in patients in the age group up to 60 years, with experience of T2DM less than 10 years, when HbA1C blood levels are more than 8 % and when insulin therapy was applied.
Conclusions. Burdening factor in the progression of DR is a gradual increase in blood pressure in a group of patients with type 2 diabetes with worse glycemic control, under the age of 60 years, with diabetes duration less than 10 years and with the application of insulin therapy.
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