DOI: https://doi.org/10.22141/2309-8147.4.2.2016.172808

DISTRIBUTION OF GENOTYPES AND ALLELES OF POLYMORPHISM rs759853 І rs9640883 GENE AKR1B1 IN PATIENTS WITH DIABETIC RETINOPATHY, CATARACT AND TYPE 2 DIABETIS MELLITUS

S. Yu. Mogilevskyy, О. V. Bushueva

Abstract


Summary. The purpose of research – a comparison of the distribution of genotypes and alleles of SNPs rs759853 and rs9640883 AKR1B1 gene in patients with diabetic retinopathy (DR), cataract, and type 2 diabetes mellitus (DM2T). 409 people were included in investigation, which were divided into fi ve groups: 1 – 98 cataract patients who had not DM2T; 2 – 76 patients with cataract and stage I DR (no visible changes in the fundus); 3 – 64 patients with cataract and non-proliferative DR; 4 – 64 patients with cataract and proliferative DR; 5 – the control group (107 patients) without ophthalmic pathology relevant to other groups by age and sex. The results of study showed that according to polymorphism rs759853 AKR1B1 gene it was determined the reduction of the frequency of the ancestral genotype G/G, with increased frequency of heterozygous G/A in groups of patients with cataract and DM2T without retinopathy, and increase of the frequency of the mutant homozygotes A/A for DR (3,3–3,9 times). In general, in case of DR it was marked decrease of the frequency of the ancestral allele G and increasing of the frequency of the mutant allele A polymorphism rs759853 AKR1B1 gene. By polymorphism rs9640883 gene AKR1B1 it was showed signifi - cant increase of the frequency of the ancestral genotype G/G in patients SD2T (1.4–1.6 times) due to reduction of the frequency of heterozygous G/A (in 1.4–1.9 times). Since homozygous genotype A/A in general turned out to patients with DR, it was possible to justify the assumption of the role of projective rs9640883 A allele in the DR development.


Keywords


diabetic retinopathy, cataract, diabetes type 2, the gene polymorphism AKR1B1, rs759853, rs9640883

References


Могілевський С. Ю. Значення поліморфних варіантів гена AKR1B1 rs759853 та rs9640883 при діабетичній ретинопатії / С. Ю. Могілевський, Л. І. Денисюк, О. В. Бушуєва // Архів офтальмології України. – 2015. – Т. 3, № 1. – С. 32–36.

Паньків В. І. Симпозіум № 162 «Цукровий діабет: діагностичні критерії, етіологія і патогенез» / В. І. Паньків // Міжнародний ендокринологічний журнал. – 2013. – № 8. – С. 53–64.

Риков С. О. Поліморфні варіанти гена VEGF rs6921438 та rs2010963 при діабетичній ретинопатії / С. О. Риков, А. С. Гудзь, Г. Є. Захаревич // Архів офтальмології України. – 2015. – Т. 3, № 1. – С. 36–40.

Sladek R. A genome-wide association study identifi es novel risk loci for type 2 diabetes / R. Sladek, G. Rocheleau, J. Rung [et al.] // Nature. – 2007. – Vol. 445. – P. 881–885.

Abhary S. A systematic meta-analysis of genetic association studies for diabetic retinopathy / S. Abhary, A. W. Hewitt, K. P. Burdon [et al.] // Diabetes. – 2009. – Vol. 58, № 9. – P. 2137–2147.

Cho H. Genetics of diabetic retinopathy / H. Cho, L. Sobrin // Curr. Diab. Rep. – 2014. – Vol. 14, № 8. – P. 515.

Hallman D. M. Familial aggregation of severity of diabetic retinopathy in Mexican Americans from Starr County, Texas / D. M. Hallman, J. C. Huber, V. H. Gonzalez [et al.] // Diabetes Care. – 2005. – Vol. 28, № 5. – P. 1163–1168.

Zhang X. Familial clustering of diabetic retinopathy in Chongqing, China, type 2 diabetic patients /X. Zhang, Y. Gao, Z. Zhou [et al.] // Eur. J. Ophthalmol. – 2010. – Vol. 20, № 5. – P. 911–918.

Hietala K. Heritability of proliferative diabetic retinopathy / K. Hietala, C. Forsblom, P. Summanen [et al.] // Diabetes. – 2008. – Vol. 57. – P. 2176–2180.

Liew G. The role of genetics in susceptibility to diabetic retinopathy / G. Liew, R. Klein, T.Y Wong // Int. Ophthalmol. Clin. – 2009. –Vol. 49, № 2. – P. 35–52.

Suzen S. Recent studies of aldose reductase enzyme inhibition for diabetic complications / S. Suzen, E. Buyukbingol // Curr. Med. Chem. – 2003. – Vol. 10, № 15. – P. 1329–1352.


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