Approaches to the treatment of Graves’ orbitopathy: yesterday, today, tomorrow

Authors

  • O.I. Prusak Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  • E.P. Ivaniuta Bogomolets National Medical University, Kyiv, Ukraine

DOI:

https://doi.org/10.22141/2309-8147.8.2.2020.209922

Keywords:

Graves’ orbitopathy, glucocorticosteroids, radiation therapy, orbital decompression, teprotumumab, computer 3D modeling

Abstract

Background. The article highlights the main approaches to the treatment of patients with Graves’ orbitopathy (GO), which remains a topical issue in ophthalmology and endocrinology, as this pathology affects the quality of life, can lead to vision loss, which is a medical and social problem. The purpose of our work was to analyze the literature data on the main approaches to the treatment of patients with Graves’ orbitopathy, which were used in the past, the current guidelines of European Group on Graves’ Orbitopathy (EUGOGO) 2016 and prospects for new researches, to evaluate advantages and disadvantages of each method of treatment. Results. Approaches to the treatment of GO have changed over time due to the development of science and a deeper understanding of the etiology and pathogenesis of this disease. The use of corticosteroids, radiation therapy, surgical treatment are main methods used for the management of patients with GO, but each of them has advantages and disadvantages. Conclusions. EUGOGO 2016 recommends a step-by-step approach to the management of patients with GO, depending on its activity and severity and impact on the quality of life of the patient. At present, the optimal specific method of treatment has not been determined, but the study of the effect of new drugs and the use of computer 3D modeling in the preoperative phase seems quite promising.

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Published

2020-03-01

Issue

Section

Literature Review, Discussions