Effect of buffer systems and preservatives in the composition of eye drops on safe and long-term treatment of patients with dry eye disease


  • S.I. Kosuba Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  • L.P. Tutchenko Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  • O.V. Tumanova Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  • M.V. Skovron Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine




dry eye disease, preservative, buffer systems


During the last years, tear substitutes have been considered as a basic drug treatment for dry eye disease. Their effect is directed to compensation of watery component of the tear and increase of the tear film stability. Main focus is made on preservatives and buffer systems. The questions of preservatives effect on ocular surface and the possibility of using alternative means are highlighted. Data of preclinical and clinical researches are presented to prove the advantages of the exclusion of preservatives from eye drops and the level of risk of the complications if the drug containing preservative is instilled for a long period.


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